What did the Catie study find?
The CATIE finding of no difference in tardive dyskinesia risk across treatment groups is consistent with the findings of a meta-analysis of 31 randomized controlled trials, which found no greater risk of extrapyramidal symptoms between low-potency first-generation antipsychotics and second-generation antipsychotics …
What is the Catie trial?
The NIMH-funded Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Study was a nationwide public health-focused clinical trial that compared the effectiveness of older (first available in the 1950s) and newer (available since the 1990s) antipsychotic medications used to treat schizophrenia.
Does olanzapine cause weight gain?
Olanzapine elicits the most weight gain of the SGAs. The Comparison of Atypicals for First Episode (CAFE) trial demonstrated that 80% of patients treated with olanzapine gained more than 7% of their initial body weight at week 52 (McEvoy et al., 2007).
What is perphenazine used for?
Perphenazine is used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). Perphenazine is also used to control severe nausea and vomiting in adults.
What is cariprazine used for?
Cariprazine is a medication that works in the brain to treat schizophrenia. It is also known as a second-generation antipsychotic (SGA) or atypical antipsychotic. Cariprazine rebalances dopamine and serotonin to improve thinking, mood, and behavior.
What is the most effective antipsychotic?
With respect to the incidence of discontinuation, clozapine was the most effective antipsychotic drug, followed by aripiprazole. As with the survival analysis for time to discontinuation, clozapine and aripiprazole were the top ranked.
How effective are antipsychotics for schizophrenia?
After 6 weeks, the proportion of patients who showed a marked to moderate degree of improvement was 75% for those who received antipsychotic treatment and 23% for those who received placebo. There were no significant differences in efficacy between the three antipsychotics assessed.
Can olanzapine help you sleep?
Insomnia: Olanzapine has been shown to improve sleep efficiency and sleep quality when combined with an SSRI in depressed patients starting with as little as 2.5 mg (21).
Does olanzapine cause memory loss?
The 2 main hypotheses of this study were confirmed: olanzapine improved multiple cognitive domains, including those known to be important in functional outcome such as verbal learning and memory and attention, and olanzapine did not impair measures sensitive to anticholinergic drugs, including verbal and spatial memory …
What is another name for perphenazine?
Formulations. It is sold under the brand names Trilafon (single drug) and Etrafon/Triavil/Triptafen (contains fixed dosages of amitriptyline).
What does perphenazine feel like?
Drowsiness, constipation, dry mouth, dizziness, lightheadedness, blurred vision, tiredness, or unexplained weight gain may occur. If any of these effects last or get worse, notify your doctor or pharmacist promptly. Dizziness and lightheadedness can increase the risk of falling.
What does cariprazine do to the brain?