What is the treatment for Peutz-Jeghers syndrome?
How is Peutz-Jeghers syndrome (PJS) treated? Currently, there is no cure for Peutz-Jeghers syndrome (PJS). Patients undergo lifelong surveillance of organs to monitor for cancer and prevent secondary problems from the polyps.
At what age is Peutz-Jeghers syndrome diagnosed?
Another sign of PJS is the development of hamartomatous polyps of the gastrointestinal tract that can cause bleeding and blockages. The average age when gastrointestinal symptoms appear is 10 years old.
What cancers are associated with Peutz-Jeghers syndrome?
Individuals with Peutz Jeghers syndrome are at a highly increased risk of developing gastrointestinal and other cancers including breast, cervical, uterine, pancreas, and lung. The lifetime risk of developing cancer in affected individuals can be as high as 93%.
What causes Peutz Jeghers?
Causes. Peutz Jeghers syndrome is an autosomal dominant genetic condition caused by mutations in the STK11/LKB1 gene. Dominant genetic disorders occur when only a single copy of an abnormal gene is necessary for the appearance of the disease.
What is PJS illness?
Peutz-Jeghers syndrome (PJS) is a rare disorder in which growths called polyps form in the intestines. A person with PJS has a high risk of developing certain cancers.
What is Turcot’s syndrome?
Turcot syndrome is characterized by the formation of multiple benign growths (polyps) in the colon that occur in association with a primary brain tumor. These growths are associated with bleeding from the rectum, diarrhea, constipation, abdominal pain, and/or weight loss.
What is Gardner syndrome?
Gardner syndrome is a rare condition that’s characterized by multiple colorectal polyps. People with Gardner syndrome have a high risk of developing colorectal cancer early in life. Though there is currently no known cure, there are ways to manage the condition and reduce the risk of cancer.
What is Muir Torre syndrome?
Muir–Torre syndrome is a rare, autosomal-dominant, genetic condition. It is defined by the occurrence of sebaceous tumours (sebaceous adenoma, epithelioma or carcinoma and/or kerato-acanthoma) and visceral malignancies. The most common visceral malignancy associated with Muir–Torre syndrome is colorectal cancer.