What is HCV genotyping test?
HCV can be diagnosed by the detection of the anti-HCV antibody in the serum or plasma samples, where a non-reactive result is considered as absence of HCV infection. Further, to declare an HCV infection as active infection, it needs to be confirmed by HCV RNA test.
What is the most common HCV genotype?
HCV subtypes 1a and 1b are the most common genotypes in the United States (Fig. 3) (145). These subtypes also are predominant in Europe (35, 82, 91).
What does HCV genotype 1a mean?
Hepatitis C virus (HCV) genotype 1 is the most prevalent worldwide. Subtype 1a, compared with 1b, shows lower response rates and higher propensity to select for drug resistance to NS3 and selected NS5A and nonnucleoside NS5B inhibitors.
How many genotypes of HCV are there?
HCV genomic analysis by means of an arduous gene sequencing of many viruses has led to the division of HCV into six genotypes based on homology. Numerous subtypes have also been identified. Arabic numerals denote the genotype, and lower-case letters denote the subtypes for lesser homology within each genotype.
Why is HCV genotype important?
Knowing your HCV genotype is important information that can help patients and doctors find the most effective treatment. All HCV genotypes cause the same amount of liver damage.
Which HCV genotype is easiest to treat?
In the United States, hepatitis C genotype 3 is less commonly contracted than genotype 1, but genotype 3 is also harder to treat….Genotype 3 has been found to respond better to newer drug combinations, including:
- glecaprevir-pibrentasvir (Mavyret)
- sofosbuvir-velpatasvir (Epclusa)
- daclatasvir-sofosbuvir (Sovaldi)
Is HCV genotype 1a curable?
One of these drugs is sofosbuvir. With PEG/ribavirin treatment alone, genotype 1 HCV used to require the longest duration of treatment with the least likelihood of success. With sofosbuvir, genotype 1 is now curable in more than 95 percent of people treated for only 12 weeks.
Can HCV genotype change?
Six major genotypes of the hepatitis C virus (HCV) have been described; it is assumed to be uncommon for genotypes to change in chronically infected individuals.
Which HCV genotype is hardest to treat?
Summary Points
- In the DAA era, HCV genotype 3 has emerged as the most difficult HCV genotype to treat.
- For treatment-naïve adults without cirrhosis, two regimens are recommended with equal evidence rating: (1) glecaprevir-pibrentasvir for 8 weeks, or (2) sofosbuvir-velpatasvir for 12 weeks.