What is the cause of cutis aplasia?
Causes. Aplasia Cutis Congenita is a rare disorder that may be inherited as an autosomal dominant or autosomal recessive trait. Human traits, including the classic genetic diseases, are the product of the interaction of two genes, one received from the father and one from the mother.
What is aplasia cutis?
Summary. Aplasia cutis congenita is a condition in which there is congenital (present from birth) absence of skin, with or without the absence of underlying structures such as bone. It most commonly affects the scalp, but any location of the body can be affected.
What medications cause aplasia cutis?
Background: Aplasia cutis congenita (ACC) following in utero exposure to antithyroid drugs such as methimazole/carbimazole (MTZ/CMZ) has been reported since 1972.
What is Adams Oliver Syndrome?
General Discussion. Adams-Oliver syndrome (AOS) is a rare inherited condition present at birth that involves changes to the limbs and scalp. Symptoms may include areas of missing skin on the scalp, limb abnormalities, heart defects, neurological concerns, and issues with the eyes.
What is aplasia baldness?
Alopecia areata is a condition that causes your hair to fall out in patches. These patches may connect and then become more noticeable. The condition develops when your immune system attacks the hair follicles causing hair loss.
What is aplasia and hypoplasia?
Aplasia, “a” means “no” and “plasia” means development. So aplasia means “no development”, and “hypo” means “under” so hypoplasia is “under formation”. In a nutshell, atrophy is the reduction in size of a cell, organ, or tissue, after it has attained its normal, matured growth.
Is Cutis aplasia life threatening?
Aplasia cutis congenita is a rare congenital anomaly characterized by the absence of a patch of skin since birth. It may lead to life threatening complications at times.
How is Cutis aplasia diagnosis?
Diagnosis. Complex cutis aplasia is diagnosed at birth when babies are born with an absence of skin and possibly underlying soft tissue and skull bone which may leave the dura (the outer covering of the brain) exposed.
What is Highlander syndrome?
The development of highlander syndrome in human patients suggests that humans might possess the genes that enable the property of eternal youth. The actualization of eternal youth is a long-held dream, and numerous studies have been performed to elucidate the mechanisms of aging and to achieve eternal youth.
What is Stickler syndrome?
Stickler syndrome is a genetic disorder that can cause serious vision, hearing and joint problems. Also known as hereditary progressive arthro-ophthalmopathy, Stickler syndrome is usually diagnosed during infancy or childhood.
What is aplasia and what causes it?
Aplasia is a condition in which an organ, limb, or other body part does not develop. In most cases, aplasia is obvious at birth. However, certain types of aplasia may sometimes not be apparent until later in life. In this article, we look at the causes and symptoms of different types of aplasia.
What causes aplasia cutis congenita?
Aplasia Cutis Congenita Symptoms and Treatment. In some cases, the condition may be caused by exposure to methimazole, a drug used to treat hyperthyroidism. Other cases may also be caused by a virus or any injury to the baby during pregnancy. If the condition is inherited, it is usually only passed down by one parent.
How does superficial aplasia cutis affect the body?
Superficial aplasia cutis involves only the epidermis (upper layers of skin). Shallow defects usually heal over before the child is born, leaving a scar. Deeper defects can extend through the dermis, subcutaneous tissue, and rarely periosteum, skull, or dura.
What are the treatment options for aplasia cutis?
Very large scalp defects, especially those with the hair collar sign, should be investigated for possible underlying bone or soft tissue defects. Most often, the only treatment required for aplasia cutis congenital is a gentle cleansing of the affected area and the application of silver sulfadiazine to prevent the patch from drying out.