How do you take SAPHRIS?
You place SAPHRIS under your tongue. SAPHRIS is not chewed or swallowed. Firmly press and hold thumb button, then pull out the tablet pack.
How do you administer asenapine?
SAPHRIS is a sublingual tablet. To ensure optimal absorption, patients should be instructed to place the tablet under the tongue and allow it to dissolve completely. The tablet will dissolve in saliva within seconds.
How do you take asenapine sublingual tablets?
Place your dose of this medication under the tongue and allow it to dissolve completely in your saliva. Do not chew, crush, split, or swallow the tablet whole. Do not eat or drink anything for 10 minutes after taking this medication.
When should asenapine be taken?
Asenapine is used to treat schizophrenia in adults. It is also used alone or together with lithium or valproate to treat symptoms of psychotic (mental) disorders, such as mania or bipolar disorder. This medicine should not be used to treat behavioral problems in older adult patients who have dementia.
What happens if you swallow asenapine?
If swallowed, the bioavailability of asenapine is limited to less than 2% because of high hepatogastrointestinal first-pass metabolism. Patient instructions are to place the tablet under the tongue and not to eat or drink for 10 minutes after administration.
Can you take Saphris once a day?
These findings suggest that asenapine once daily dosing, as compared to the recommended twice daily regimen, is associated with better patient acceptance, reduced daytime drowsiness, and equal to greater psychopathology improvement in patients with schizophrenia or schizoaffective disorder.
How long does it take Saphris to dissolve?
Do not eat or drink for 10 minutes after taking asenapine. The sublingual tablets will dissolve within seconds when placed under your tongue. They should not be split, crushed, chewed, or swallowed. Asenapine orally disintegrating tablets must remain in their original packaging.
Does Saphris work immediately?
How long does it take for asenapine (Saphris) to work? You can expect asenapine (Saphris) to start working in 1 to 2 weeks, but it may take several weeks until you feel the full effects. Some people might see continued improvement with this medication during the first 3 to 4 months of taking it.
How fast does SAPHRIS work?
Does SAPHRIS make you sleepy?
Drowsiness, dizziness, lightheadedness, and weight gain may occur. Numbness/tingling of the mouth may also occur but usually goes away within 1 hour. Sores, blisters, or pain under the tongue may rarely occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Can you take Saphris at night?
The US Food and Drug Administration recommended dose for asenapine as the acute treatment of schizophrenia is 5 mg twice daily,3 but its terminal half-life of approximately 24 hours3 suggests that it can be administered as a single bedtime dose.
How fast does Saphris work?
What is the primary efficacy rating scale for Saphris?
In the two positive trials for SAPHRIS, the primary efficacy rating scale was the Positive and Negative Syndrome Scale (PANSS).
How do I take Saphris?
SAPHRIS is a sublingual tablet. To ensure optimal absorption, patients should be instructed to place the tablet under the tongue and allow it to dissolve completely. The tablet will dissolve in saliva within seconds.
Is there a dosage adjustment for Saphris for patients with hepatic impairment?
No dosage adjustment for SAPHRIS is required in patients with mild to moderate hepatic impairment (Child-Pugh A and B) because asenapine exposure is similar to that in subjects with normal hepatic function [see CONTRAINDICATIONS and CLINICAL PHARMACOLOGY ].
When should Saphris be taken for high body temperature?
Appropriate care is advised when prescribing SAPHRIS for patients who will be experiencing conditions that may contribute to an elevation in core body temperature, e.g., exercising strenuously, exposure to extreme heat, receiving concomitant medication with anticholinergic activity, or being subject to dehydration.