What is the role of aggrecan?
Aggrecan is the major proteoglycan in the articular cartilage. This molecule is important in the proper functioning of articular cartilage because it provides a hydrated gel structure (via its interaction with hyaluronan and link protein) that endows the cartilage with load-bearing properties.
What is aggrecan degradation?
Aggrecan degradation is the hallmark of cartilage degeneration in osteoarthritis (OA), though it is unclear whether a common proteolytic process occurs in all individuals.
Is aggrecan in hyaline cartilage?
Abstract. Hyaline cartilage contains five well-characterized proteoglycans in its extracellular matrix, and it is likely that others exist. The largest in size and most abundant by weight is aggrecan, a proteoglycan that possesses over 100 chondroitin sulfate and keratan sulfate chains.
Is aggrecan found in bone?
Aggrecan is the major structural macromolecule of cartilage, which contributes to water retention and provides resistance to compression. Whereas cartilage is localized on the joint surface and help movement of individuals, it serves as a primodium of most bones during development.
Is Aggrecan a gag?
Aggrecan is a high molecular weight (1×106 < M < 3×106) proteoglycan. It exhibits a bottlebrush structure, in which chondroitin sulfate and keratan sulfate glycosaminoglycan (GAG) chains are attached to an extended protein core.
What is Lubricin and what is its function in the knee joint?
Lubricin is a surface-active mucinous glycoprotein secreted in the synovial joint that plays an important role in cartilage integrity. In healthy joints, lubricin molecules coat the cartilage surface, providing boundary lubrication and preventing cell and protein adhesion.
What does chondroitin supplement do?
Chondroitin helps keep cartilage healthy by absorbing fluid (particularly water) into the connective tissue. It may also block enzymes that break down cartilage, and it provides the building blocks for the body to produce new cartilage.
How does aggrecan affect cartilage function?
The function of aggrecan in articular cartilage. In the relaxed state the aggregates swell as the anionic chondroitin sulfate and keratan sulfate chains draw water into the tissue until an equilibrium is attained in which swelling is balance by tensile forces in the collagen fibrils.
Is aggrecan a glycosaminoglycans?
Structure. Aggrecan is a high molecular weight (1×106 < M < 3×106) proteoglycan. It exhibits a bottlebrush structure, in which chondroitin sulfate and keratan sulfate glycosaminoglycan (GAG) chains are attached to an extended protein core. Aggrecan has a molecular mass >2,500 kDa.
Is aggrecan a CSPG?
The following CSPGs have been identified: Aggrecan (CSPG1) Versican (CSPG2)
How does Aggrecan affect cartilage function?
Is Aggrecan extracellular matrix?
Aggrecan Directs Extracellular Matrix-Mediated Neuronal Plasticity – PMC. The . gov means it’s official.
What is aggrecan?
The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage . Aggrecan is a proteoglycan, or a protein modified with large carbohydrates; the human form of the protein is 2316 amino acids long and can be expressed in multiple isoforms due to alternative splicing.
What is aggrecan in cartilage?
Aggrecan is a large keratan sulfate/chondroitin sulfate-linked proteoglycan (∼2500 kDa), which is prominent in cartilage, but also present in the brain, aorta, and tendons. Its N-terminal domain binds to hyaluronan, an interaction stabilized by link protein.
What is the function of aggrecan domain?
Aggrecan is a critical component for cartilage structure and the function of joints. Functionally, the G1 domain interacts with hyaluronic acid and link protein, forming stable ternary complexes in the extracellular matrix. G2 is homologous to the tandem repeats of G1 and of link protein and is involved in product processing.
Is aggrecan a type 2 collagen?
Along with type-II collagen, aggrecan forms a major structural component of cartilage, particularly articular cartilage . The aggrecan family includes other important members such as versican, also named PG-M, neurocan, brevican and the cell surface HA receptor CD44.
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