Can daptomycin cause pneumonia?
Daptomycin-induced eosinophilic pneumonia is characterized by febrile illness, hypoxemia, diffuse bilateral pulmonary infiltrates, and bronchoalveolar lavage (BAL) with greater than 25% eosinophils. If this presentation occurs for a maximum of 5 days, it is characterized as acute eosinophilic pneumonia.
Can Covid cause eosinophilic pneumonia?
We report a case of acute eosinophilic pneumonia (AEP) triggered by coronavirus disease 2019 (COVID‐19) infection. This case suggests the importance of considering the complications of AEP when treating patients with COVID‐19 infection.
How does daptomycin cause eosinophilic pneumonia?
Although the mechanism of daptomycin-induced eosinophilic pneumonia is unknown, some have speculated that daptomycin may bind to human surfactant and accumulate in the alveolar space causing injury to the epithelium with resulting inflammation [7, 8].
Why can’t daptomycin be used in pneumonia?
Daptomycin should not be used to treat pneumonia. This is due to the fact that daptomycin is inhibited by surfactant (Silverman et al 2005).
What are the side effects of daptomycin?
More common
- Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site.
- difficulty having a bowel movement.
What is eosinophilic pneumonia?
General Discussion. Acute eosinophilic pneumonia (AEP) is a rare disorder characterized by the rapid accumulation of eosinophils in the lungs (pulmonary eosinophilia). Eosinophils are a type of white blood cell and are part of the immune system.
Can vaccines raise eosinophils?
71 Eosinophil-associated disease enhancement following exposure after vaccination is unfortunately not a new phenomenon. Historical reports from the 1960s link administration of a candidate formalin-inactivated RSV vaccine to severe, eosinophil-associated pulmonary disease following natural infection.
When should you not take daptomycin?
Contraindications
- Clinical Consideration. Daptomycin is contraindicated in patients with a known hypersensitivity reaction to the drug or any component within the formulation.
- Geriatric Patients.
- Pregnancy.
- Breastfeeding.
- Renal Impairment.
- Bacterial Resistance.
- Drug Interactions.
Does daptomycin work in the lung?
Daptomycin exhibited an unusual pattern of activity in pulmonary animal models: efficacy in Staphylococcus aureus hematogenous pneumonia and inhalation anthrax but no activity against Streptococcus pneumoniae in simple bronchial-alveolar pneumonia.
Is daptomycin a high risk medication?
This medication is an antibiotic used to treat serious bacterial infections. It works by stopping the growth of bacteria. This medication is not recommended for use in children younger than 12 months due to possible risk of serious side effects.
What should I monitor while on daptomycin?
Patients should also receive monitoring for muscle pain or weakness, new-onset or worsening peripheral neuropathy, and signs or symptoms of eosinophilic pneumonia. [14][18] Furthermore, patients who develop diarrhea should have testing for C. difficile infection.
How do you treat eosinophilic pneumonia?
Eosinophilic pneumonia may be mild, and people with the disease may get better without treatment. For acute eosinophilic pneumonia, a corticosteroid such as prednisone is usually needed. In chronic eosinophilic pneumonia, prednisone may be needed for many months or even years.
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