Is meperidine a CII?
DEMEROL contains meperidine, a mu-agonist opioid with an abuse liability similar to morphine and is a Schedule II controlled substance.
What is meperidine PF?
Meperidine is used to help relieve moderate to severe pain. It may also be used before and during surgery or other procedures. Meperidine belongs to a class of drugs known as opioid analgesics and is similar to morphine. It works in the brain to change how your body feels and responds to pain.
What is the indication of meperidine?
DEMEROL Tablets and Oral Solution are indicated for the management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.
Why was meperidine discontinued?
Many clinicians recommend that meperidine be removed from health-systems or that its use be restricted, due to concerns about adverse reactions, drug interactions, and normeperidine neurotoxicity. In addition, clinical evidence shows that meperidine has no advantage over other opioids for biliary colic or pancreatitis.
What is the difference between a Schedule 1 and 2 drug?
Schedule I — drugs with a high abuse risk. These drugs have NO safe, accepted medical use in the United States. Some examples are heroin, marijuana, LSD, PCP, and crack cocaine. Schedule II — drugs with a high abuse risk, but also have safe and accepted medical uses in the United States.
What precautions do you need to take while administering the meperidine Demerol )?
Do not drink alcohol, take prescription or nonprescription medications that contain alcohol, or use street drugs during your treatment. Do not allow anyone else to take your medication. Meperidine may harm or cause death to other people who take your medication, especially children.
What is meperidine hydrochloride IV?
A drug used to treat moderate to severe pain. It binds to opioid receptors in the central nervous system. Meperidine hydrochloride is a type of analgesic agent and a type of opioid. Also called Demerol.
What are the effects of meperidine?
Nausea, vomiting, constipation, sweating, lightheadedness, dizziness, or drowsiness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. To prevent constipation, eat dietary fiber, drink enough water, and exercise. You may also need to take a laxative.
What can I monitor with meperidine?
Monitor closely for signs of respiratory depression and sedation. meperidine and St John’s Wort both increase serotonin levels. Avoid or Use Alternate Drug.
Is meperidine still being manufactured?
This medicine is available only under a restricted distribution program called the Opioid Analgesic REMS (Risk Evaluation and Mitigation Strategy) program. This product is available in the following dosage forms: Syrup.
What company makes meperidine?
DEMEROL (Meperidine Hydrochloride Injection, USP) | Pfizer Medical Information – US.
How do clinicians use meperidine?
Clinicians use meperidine is used for the treatment of moderate to severe pain. It has intramuscular, subcutaneous, intravenous injection, syrup, and tablet forms. In the 20th century, it was the drug of choice amongst the opioids in the management of acute pain by most of the physicians and the management of some patients with chronic pain.
Is meperidine hydrochloride a controlled substance?
Meperidine Hydrochloride Tablets and Oral Solution contain Meperidine, a Schedule II controlled substance. As an opioid, Meperidine exposes users to the risks of addiction, abuse and misuse [see Drug Abuse and Dependence (9)].
Does meperidine increase intracranial pressure?
In patients who may be susceptible to the intracranial effects of CO2 retention (e.g., those with evidence of increased intracranial pressure or brain tumors), Meperidine may reduce respiratory drive, and the resultant CO2 retention can further increase intracranial pressure.
What are the long-term effects of pro-prolonged meperidine use?
Prolonged Meperidine use may increase the risk of toxicity (e.g. seizures) from the accumulation of the Meperidine metabolite, norMeperidine.