What drug is a fluoroquinolone?
Fluoroquinolones are a class of antibiotics approved to treat or prevent certain bacterial infections. The fluoroquinolone antibiotics include ciprofloxacin (Cipro), gemifloxacin (Factive), levofloxacin (Levaquin), moxifloxacin (Avelox), and ofloxacin (Floxin).
What is fluoroquinolone used for?
The fluoroquinolones are a family of broad spectrum, systemic antibacterial agents that have been used widely as therapy of respiratory and urinary tract infections. Fluoroquinolones are active against a wide range of aerobic gram-positive and gram-negative organisms.
How is delafloxacin different from other fluoroquinolones?
Delafloxacin (formerly WQ-3034, ABT492, RX-3341) is a novel fluoroquinolone chemically distinct from currently marketed fluoroquinolones with the absence of a protonatable substituent conferring a weakly acidic character to the molecule.
What is the difference between quinolones and fluoroquinolones?
There are several different types of antibiotics that may be used for various infections, but quinolones (also known as fluoroquinolones) are a type of infectious disease medication used primarily when there is a concern for multidrug resistance from other antibiotics.
Who should not take fluoroquinolones?
The FDA advises that health care providers should not prescribe systemic fluoroquinolones for patients who have an aortic aneurysm or are at risk of an aortic aneurysm (such as patients with peripheral atherosclerotic vascular diseases, hypertension, certain genetic conditions such as Marfan syndrome and Ehlers-Danlos …
What are side effects of fluoroquinolones?
Common side effects of fluoroquinolones include nausea, diarrhea, vomiting, abdominal pain or discomfort, and trouble sleeping. Some patients also develop sensitivity to sunlight and ultraviolet light, such as the lights used in tanning salons.
Does delafloxacin cause QT prolongation?
Interestingly, delafloxacin did not demonstrate QTc prolongation in phase III clinical trials. Delafloxacin was also not associated with a clinically meaningful effect on QTc interval compared to moxifloxacin in a randomized, double-blind, four-period crossover study of 52 healthy adults.
How does delafloxacin work?
Delafloxacin belongs to the class of drugs, known as quinolone antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections. This medicine is available only with your doctor’s prescription.
Why should you avoid fluoroquinolones?
Fluoroquinolone antibiotics can increase the occurrence of rare but serious events of ruptures or tears in the main artery of the body, called the aorta. These tears, called aortic dissections, or ruptures of an aortic aneurysm can lead to dangerous bleeding or even death.
Is azithromycin A fluoroquinolones?
Azithromycin is a semisynthetic macrolide antibiotic, whereas levofloxacin is a fluoroquinolones antibiotic. Since its release in early 1990s, azithromycin has become the most commonly prescribed macrolide antibiotics in the US.
Who is at risk for fluoroquinolone toxicity?
The U.S. Food and Drug Administration today issued a Drug Safety Communication warning health care professionals to avoid prescribing fluoroquinolone antibiotics to patients who have an aortic aneurysm or are at risk for an aortic aneurysm, such as patients with a history of blood vessel blockages or aneurysms, high …
Are fluoroquinolones safe?
Generally, these drugs are well tolerated and have proven to be safe and efficacious antimicrobial agents. Fluoroquinolones continue to be contraindicated for pregnant women; however, a growing body of evidence suggests that these drugs are safe in children.