What is Hyper-CVAD regimen?
An abbreviation for a chemotherapy combination used to treat some types of acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL). Hyper-CVAD regimen includes the drugs cyclophosphamide, vincristine sulfate, doxorubicin hydrochloride (Adriamycin), and dexamethasone.
What is Calgb regimen?
The CALGB 19802 regimen is characterized by early dose intensification of daunorubicin during induction and post-remission therapy and high-dose cytarabine and methotrexate during post-remission therapy.
What Calgb 10403?
CALGB 10403 treatment consisted of induction, consolidation, interim maintenance, delayed intensification, and long-term maintenance therapy (detailed dosing schedule provided in Figure 1) and replicated exactly 1 arm of the Children’s Oncology Group (COG) randomized study AALL0232 for high-risk childhood ALL.
What is asparaginase used for?
Asparaginase is a chemotherapy drug. You might have it as a treatment for acute lymphoblastic leukaemia (ALL).
How is hyper-CVAD administered?
Hyper-CVAD is given as hyperfractionated therapy, in which the total daily dose is divided into smaller doses and given more than once a day. This combination may also be used with other drugs or treatments or to treat other types of cancer.
How often is hyper-CVAD given?
HyperCVAD Part A is alternated with HyperCVAD Part B every 21 days. This sometimes takes longer if waiting for normal blood counts recover after the previous cycle. When both Part A and Part B are completed, this is known as one Cycle.
What is 6 mercaptopurine used for?
MERCAPTOPURINE, 6-MP (mer kap toe PYOOR een) is a chemotherapy drug. It interferes with the growth of cancer cells and can reduce immune system activity. It is used to treat certain types of acute leukemia.
What is Gmall protocol?
The GMALL study group developed these protocols based on concepts employed successfully in the treatment of paediatric mature B-ALL. All used short, alternating cycles of intensive chemotherapy (in an ABABAB pattern) that included high doses of methotrexate and cyclophosphamide.
What is Capizzi style methotrexate?
Capizzi-Style Methotrexate with Pegasparagase (C-MTX) Is Superior to High-Dose Methotrexate (HDMTX) in T-Lineage Acute Lymphoblastic Leukemia (T-ALL): Results from Children’s Oncology Group (COG) AALL0434.
What is pomp maintenance?
POMP maintenance therapy is typically given after all cycles of therapy are completed. On occasion, POMP therapy may be used as the primary method of treating leukemia. Examples of regimens that use POMP maintenance may include: HyperCVAD A, HyperCVAD B.
What class of drug is asparaginase?
EnzymeAsparaginase / ClassificationEnzymes are proteins that act as biological catalysts. Catalysts accelerate chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. Wikipedia
How do you give asparaginase?
Aspariginase is given as an injection into a large muscle (intramuscular or IM). Depending on your dose, the medication may need to be divided into two injections. Also may be given into the vein as an infusion (intravenous or IV). This method has higher risk of allergic reaction so often a test dose is given first.
What do the arrows mean in the Hyper-CVAD and modified Hyper-CVAD regimens?
Schema for the hyper-CVAD and modified hyper-CVAD regimens. Arrows indicate intrathecal chemotherapy administrations.
Which medications are used in the treatment of hyper-CVAD?
Intensification of hyper-CVAD with asparaginase, vincristine, and dexamethasone is active in ALL salvage producing a CR rate of 45%. Further improvements should include:
How can the Hyper-CVAD regimen be modified to improve outcome?
Modification of the hyper-CVAD regimen with anthracycline intensification did not improve outcome. Other modifications of the program could include incorporation of monoclonal antibodies and/or nucleoside analogs, particularly for slow responders or those with residual mediastinal disease.
What should be included in the maintenance dose of HyperCVAD?
Any dose reductions or omissions made during the intensive hyperCVAD phase should be continued during maintenance as well. In cases of liver dysfunction and total bilirubin >2 mg/dL, vincristine must be omitted.