What is the basic pathophysiology of systemic lupus erythematosus?
The basic pathological features of SLE are that of inflammation and blood vessel abnormalities, which include band or occlusive vasculopathy, vasculitis, and immune complex deposition. The best characterised organ pathology is in the kidney.
How is systemic lupus erythematosus managed?
Antimalarials and low-dose glucocorticoids are first-line agents used to treat arthritis pain associated with SLE. Hydroxychloroquine is favored over chloroquine (Aralen) because it is less toxic. Nonsteroidal anti-inflammatory drugs can be used as adjunctive therapy to treat joint pain.
What is the classification of systemic lupus erythematosus?
What is the classification of systemic lupus erythematosus (SLE) nephritis?
Class | Classification |
---|---|
Class I | Minimal mesangial |
Class II | Mesangial proliferative |
Class III | Focal proliferative |
Class IV | Diffuse proliferative |
What is a common diagnostic criteria for identifying systemic lupus erythematosus SLE?
Antinuclear antibody titer is the primary laboratory test used to diagnose systemic lupus erythematosus. Because of the low prevalence of the disease in primary care populations, the antinuclear antibody titer has a low predictive value in patients without typical clinical symptoms.
What organs are affected by systemic lupus erythematosus?
Some of the organ systems that can be affected by lupus or lupus medications are:
- Central Nervous system (brain and spinal cord)
- Ophthalmologic system (eyes)
- Oral system (mouth)
- Dermatologic system (skin)
- Cardiopulmonary system (heart and lungs)
- Renal system (kidney)
- Gastrointestinal system (digestive)
What is the difference between lupus and systemic lupus?
When people use the term “lupus,” they usually refer to systemic lupus erythematosus, or “SLE.” Throughout this website, the term “lupus” is used to signal systemic lupus, since SLE constitutes the most common form of the disease. Systemic lupus is so-named because it affects many different organ systems in the body.
What is standard therapy for lupus?
Lupus is mainly treated with medicine. The types of drugs that have been used to treat lupus include NSAIDs, corticosteroids and other immune system suppressing drugs, hydroxychloroquine, and the newest lupus drug, Benlysta.
What’s new in the treatment of systemic lupus erythematosus?
Daratumumab treatment resulted in remarkable clinical outcomes not only of severe manifestations such as lupus nephritis, autoimmune hemolytic anemia and autoimmune thrombocytopenia but also on less severe manifestations such as arthritis, skin rashes, pericarditis, cutaneous vasculitis, alopecia, and mucosal ulcers.
Which antibody is most specific for SLE?
The antinuclear antibody (ANA) test is the most sensitive test for SLE and is therefore the best screening assay for ruling out its presence.
Is lupus erythematosus Tubuh?
Lupus atau yang lebih dikenal dengan Systemic Lupus Erythematosus pada kalangan medis, adalah penyakit sistem kekebalan tubuh. Biasanya, sistem kekebalan tubuh melindungi tubuh dari infeksi.
What is systemic lupus erythematosus?
Systemic lupus erythematosus (SLE), is the most common type of lupus. SLE is an autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage in the affected organs. It can affect the joints, skin, brain, lungs, kidneys, and blood vessels.
Is lupus penyakit Menular?
Perlu diingat, lupus bukanlah penyakit menular. Lupus dapat menyebabkan peradangan di berbagai organ dan bagian tubuh. Hal ini menyebabkan gejala lupus bisa sangat beragam dan berbeda antara satu penderita dengan penderita lain. Meski demikian, terdapat sejumlah umum yang bisa terjadi, yaitu: Lupus adalah penyakit yang sulit didiagnosis.
What is the treatment for systemic lupus erythematosus?
SLE treatment consists primarily of immunosuppressive drugs that inhibit activity of the immune system. Hydroxychloroquine and corticosteroids (e.g., prednisone) are often used to treat SLE. The FDA approved belimumab in 2011, the first new drug for SLE in more than 50 years.