What percentage of dengue is severe?
Approximately 1 in 20 patients with dengue virus disease progress to develop severe, life-threatening disease called severe dengue.
How do you measure viremia?
Viremia was calculated by using a singleplex qRT-PCR and standard curves obtained by serial dilutions of DENV-1 and DENV-2 stocks titrated by plaque assays in BHK-21 cells23 and expressed as plaque-forming units per milliliter equivalents (PFUeq/mL).
What is DHF and DSS in dengue?
The symptomatic cases are categorized as undifferentiated febrile illness (UF), dengue fever (DF), dengue hemorrhagic fever (DHF), dengue shock syndrome (DSS) and unusual dengue (UD) or expanded dengue syndrome (EDS) [1].
What is the death ratio of dengue?
The World Health Organization has estimated that dengue viruses infect > 50 million persons worldwide each year. A total of 1% of these persons are given a diagnosis of dengue hemorrhagic fever (DHF) and of these persons, the disease causes death in approximately 4% of the cases.
Can you get dengue twice?
Once a person has been infected with one strain, their body will build up an immunity to only that strain of the virus. This means that a person can become infected with dengue fever another 3 times in their life. Moreover, each dengue fever reinfection is much more dangerous than the previous infection.
What is IgG positive in dengue test?
Positive IgM and IgG tests for dengue antibodies detected in an initial blood sample mean that it is likely that the person became infected with dengue virus within recent weeks. IgM antibody tests can be positive if a person has been infected with a similar virus, such as chikungunya (called cross-reaction).
What is viremia in dengue?
Viremia is strongly associated with disease severity and type of infection which gave viremia a high indicative power to be used as a clinical predictor. Dengue serotype is also associated with viral load with higher viremia in DENV-2/1.
What is the difference between DF and DHF?
Dengue fever (DF) is an acute febrile viral disease frequently presented with headache, bone or joint and muscular pains, and rash. A significant percentage of DF patients develop a more severe form of disease, known as dengue haemorrhagic fever (DHF). DHF is the complication of DF.
What is Frank shock?
Dengue Shock Syndrome (DSS) is defined as hypotension, narrow pulse pressure (£20 mm Hg), or frank shock in any case patient whose illness meets the criteria for DHF. From: CDC Health Information for International Travel 2010, 2009.
What is the incidence of dengue?
The incidence of dengue has grown dramatically around the world in recent decades. A vast majority of cases are asymptomatic or mild and self-managed, and hence the actual numbers of dengue cases are under-reported. Many cases are also misdiagnosed as other febrile illnesses.
What is the virus responsible for causing dengue?
The virus responsible for causing dengue, is called dengue virus (DENV). There are four DENV serotypes and it is possible to be infected four times. Severe dengue is a leading cause of serious illness and death in some Asian and Latin American countries.
What do you need to know about dengue?
Dengue and severe dengue 1 Global burden of dengue. The incidence of dengue has grown dramatically around… 2 Transmission. The Aedes aegypti mosquito is the primary vector of dengue. 3 Characteristics. Dengue fever is a severe, flu-like illness that affects infants,… 4 Treatment. There is no specific treatment for dengue fever.
What is the role of DC-SIGN in the pathogenesis of dengue?
“DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells”. The Journal of Experimental Medicine. 197 (7): 823–9. doi: 10.1084/jem.20021840. PMC 2193896. PMID 12682107.